DiscoverThe Proof with Simon HillMetabolic health truths | Christos Mantzoros MD, DSc, PhD
Metabolic health truths | Christos Mantzoros MD, DSc, PhD

Metabolic health truths | Christos Mantzoros MD, DSc, PhD

Update: 2024-07-151
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Episode #322. Did you know that 30% of cancers are related to obesity? Join me as I sit down with Harvard Professor and endocrinologist Dr Christos Mantzoroz to discuss fatty liver disease, metabolic health, and hormones.

You’ll learn about why so many people are obese and whether you can be overweight and healthy. Dr Mantzoroz breaks down budget-friendly ways to evaluate your metabolic health, explains how hormones affect your weight, and offers his insight on how to treat obesity. Overall, this episode is a masterclass in metabolic health and fatty liver disease.


Specifically, we discuss:


  • Introduction to The Latest Obesity Research Findings (00:00 )

  • The Evolving Understanding of Obesity Science (03:49 )

  • Uncovering New Fat Storage Mechanisms (10:57 )

  • Modern Techniques for Accurate Body Fat Measurement (15:02 )

  • Why Maintaining Weight Loss Is So Challenging (20:01 )

  • Evolutionary Insights into Human Fat Storage (25:12 )

  • How Leptin Regulates Energy Balance and Health (29:17 )

  • New Approaches to Break Through Weight Set Points (39:27 )

  • Environment's Role in Weight Gain Beyond Diet (45:49 )

  • Decoding the Genetics of Fat Storage and Metabolism (52:59 )

  • Non-Alcoholic Fatty Liver Disease Explained (55:40 )

  • Evidence-Based Nutrition for Optimal Liver Health (01:05:25 )

  • Promising Advances in Non-Invasive Liver Tests (01:10:49 )

  • Oestrogen's Impact on Metabolism (01:20:14 )

  • The Link Between Liver Fat and Insulin Resistance (01:22:04 )

  • Addressing America's Growing Metabolic Health Crisis (01:26:11 )

  • Outro (01:27:11 )


Connect with Christos Mantzoros, MD DSc PhD h.c. mult. on LinkedIn, and discover his work here.

This episode is brought to you by:

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Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

Watch the episodes on YouTube or listen on Apple/Spotify

Connect with me on InstagramTwitter, and Facebook

Nourish your gut with my Plant-Based Ferments Guide

Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

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Metabolic health truths | Christos Mantzoros MD, DSc, PhD

Metabolic health truths | Christos Mantzoros MD, DSc, PhD

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